SELinux blocks CVE-2006-3626 (local privilege escalation)
It’d be an interesting and useful exercise to go back through historical vulnerabilities and determine how many of them would be mitigated by SELinux and similar technologies (Exec-shield, PIE etc.).
Mark Cox wrote an interesting paper, Risk Report: A year of Red Hat Enterprise Linux 4, which mentions that SELinux blocked the Lupper worm (also noting that that the policy version shipped by default would not have blocked a modified version of the worm).
SELinux mitigation confirmed by SANS. They also mention mounting /proc as nosuid as a workaround.